Hoda Kotb Admits To Keeping In Touch With Disgraced Today Host Matt Lauer: ‘This Is One Of Those Complex Situations’

Hard times.

As you know, Hoda Kotb replaced Matt Lauer as co-anchor of the Today show alongside Savannah Guthrie earlier this year after the longtime journalist was exposed as a serial sexual harasser.

In The Hollywood Reporter‘s article for the 35 Most Powerful People in New York Media 2018 issue, the 53-year-old admitted that she’s stuck between a rock and a hard place because of her friendship with Lauer.

Related: Ryan Seacrest Accuser Thinks Megyn Kelly Canceled Interview To Protect Company!

She said she still communicates with the 60-year-old, who is said to be focusing on his family following the allegations:

“Yeah, we keep in touch with him. I mean look, this is one of those complex situations. I’ve known him since I started working at NBC [in 1998]. When I was sick with breast cancer, he was the first to call. He helps and helped in ways that … you know, he was incredible in that way.”

Lauer even sent Kotb a congratulatory text when she took his job.

But although they have fond memories together, Hoda is not discounting the stories of the women who accused the NBC anchor of wrongdoing:

“There is that Matt and then there’s the Matt that the accusers speak of. And those accusers’ voices matter and that story matters and it’s … (to Savannah Guthrie) It’s still tough, right?”

Savannah replied:

“Yes.”

A tough situation, sure!

[Image via Instagram.]

Read more: http://perezhilton.com/2018-04-13-hoda-kotb-matt-lauer-communication

What too much alcohol can do to your health

(CNN)This feature is part of CNN Parallels, an interactive series exploring ways you can improve your health by making small changes to your daily habits.

A lot of us drink. Too many of us drink a lot.
Worldwide, each person 15 years and older consumes 13.5 grams of pure alcohol per day, according to the World Health Organization. Considering that nearly half of the world doesn’t drink at all, that leaves the other half drinking up their share.
    While the majority of the world drinks liquor, Americans prefer beer. The Beverage Marketing Corp. tracks these things: In 2017,Americans guzzled about 27 gallons of beer (or 216 pints), 2.6 gallons of wine and 2.2 gallons of spirits per drinking-age adult.
    But Americans are lightweights in any worldwide drinking game, based on numbers from the World Health Organization. The Eastern European countries of Lithuania, Belarus, Czechia (the Czech Republic), Croatia and Bulgaria drink us under the table.
    In fact, measuring liters drunk by anyone over 15, the US ranks 36th in the category of most sloshed nation; Austria comes in sixth; France is ninth (more wine) and Ireland 15th (yes, they drink more beer), while the UK ranks 18th.
    Who drinks the least in the world? The Arab nations of the Middle East.

    With all this boozing going on, just what damage does alcohol do to your health? Let’s explore what science says are the downsides of having a tipple or two.

    Counting calories

    Even if you aren’t watching your waistline, you might be shocked at the number of empty calories you can easily consume during happy hour.
    Calories are typically defined by a “standard” drink. In the US, that’s about 0.6 fluid ounces or 14 grams of pure alcohol, which differs depending on the type of adult beverage you consume.

    For example, a standard drink of beer is one 12-ounce can (355 milliliters). For malt liquor, it’s 8 to 9 fluid ounces (251 milliliters). A standard drink of red or white wine is about 5 fluid ounces (148 milliliters).
    What’s considereda standard drink continues to go down as the alcohol content goes up. But what if that changes? Let’s use beer as an example.
    It used to be that light beer came in around 100 calories while regular beer averaged 153 calories per 12-fluid ounce can or bottle — that’s the same as two or three Oreo cookies.

    But beer calories depend on both alcohol content and carbohydrate level. So if you’re a fan of today’s popular craft beers, which often have extra carbs and higher alcohol content, you could easily face a calorie land mine in every can. Let’s say you chose a highly ranked IPA, such as Sierra Nevada Bigfoot (9.6% alcohol) or Narwhal (10.2% alcohol), and you’ve downed a whopping 318 to 344 calories, about as much as a McDonald’s cheeseburger. Did you drink just one?
    If you pour correctly, white wine is about 120 calories per 5 fluid ounces, and red is 125. If you fill your glass to the brim, that might easily double.
    Liquor? Gin, rum, vodka, tequila and whiskey cost you 97 calories per 1.5 fluid ounces, but that’s without mixers. An average margarita will cost you 168 calories while a pina colada weighs in at a whopping 490 calories, about the same as a McDonald’s Quarter Pounder.
    A 2013 study in the US found that calorie intake went up on drinking days compared with non-drinking days, mostly due to alcohol: Men took in 433 extra calories, while women added 299 calories.
    But alcohol can also affect our self-control, which can lead to overeating. A 1999 study found that people ate more when they had an aperitif before dinner than if they abstained.
    Take heart. If you’re a light to moderate drinker, meaning you stick to US guidelines of one “standard” drink a day for women and two for men, studies have shown that you aren’t guaranteed to gain weight over time — especially if you live an overall healthy lifestyle.
    For example, a 2002 study of almost 25,000 Finnish men and women over five-year intervals found that moderate alcohol consumption, combined with a physically active lifestyle, no smoking and healthy food choices, “maximizes the chances of having a normal weight.”
    However, it appears that heavy drinking and binge drinking could be linked to obesity. And that’s a problem. The numbers of binge drinkers — defined as five or more drinks for men and four or more drinks for women within a couple of hours at least once a month — has been rising in the United States.
    The Centers for Disease Control and Prevention says one in six adults binge about four times a month, downing about eight drinks in each binge.
    In the UK, where binge drinking is defined as “drinking lots of alcohol in a short space of time or drinking to get drunk,” a 2016 national survey found 2.5 million people admitted to binge drinking in the last week.
    Alcohol, of course, has no nutritional value and contains 7 calories per gram — more than protein and even carbs, which both have 4 calories. Fat has 9 calories per gram.
    All those empty alcohol calories have to end up somewhere.

    Heart disease and cancer

    The prevailing wisdom for years has been that drinking in moderation — again, that’s one “standard” drink a day for women and two for men — is linked to a lower risk of cardiovascular disease. But recent studies are casting doubt on that long-held lore. Science now says it depends on your age and drinking habits.
    A 2017 study of nearly 2 million Brits with no cardiovascular risk found that there was still a modest benefit in moderate drinking, especially for women over 55 who drank five drinks a week. Why that age? Alcohol can alter cholesterol and clotting in the blood in positive ways, experts say, and that’s about the age when heart problems begin to occur.
    For everyone else, the small protective effect on the heart was evident only if the drinks were spaced out during the week. Consuming heavily in one session, or binge drinking, has been linked to heart attacks — or what the English call “holiday heart.”
    Also, a 2018 study found that drinking more than 100 grams of alcohol per week — equal to roughly seven standard drinks in the United States or five to six glasses of wine in the UK — increases your risk of death from all causes and in turn lowers your life expectancy. Links were found with different forms of cardiovascular disease, with people who drank more than 100 grams per week having a higher risk of stroke, heart failure, fatal hypertensive disease and fatal aortic aneurysm, where an artery or vein swells up and could burst.
    In contrast, the 2018 study found that higher levels of alcohol were also linked to a lower risk of heart attack, or myocardial infarction.
    Overall, however, the latest thinking is that any heart benefit may be outweighed by other health risks, such as high blood pressure, pancreatitis, certain cancers and liver damage.
    Women who drink are at a higher risk for breast cancer; alcohol contributes about 6% of the overall risk, possibly because it raises certain dangerous hormones in the blood. Drinking can also increase the chance you might develop bowel, liver, mouth and oral cancers.
    One potential reason: Alcohol weakens our immune systems, making us more susceptible to inflammation, a driving force behind cancer, as well as infections and the integrity of the microbiome in our digestive tract. That’s true not only for chronic drinkers but for those who binge, as well.

    Diabetes

    The connection between alcohol and diabetes is complicated. Studies show that drinking moderately over three or four days a week may actually lower the risk of developing type 2 diabetes. However, drinking heavily increases the risk. Too much alcohol inflames the pancreas, which is responsible for secreting insulin to regulate your body’s blood sugars.
    If you have diabetes, alcohol may interact with various medications. If you take insulin or any pills that stimulate the release of insulin, alcohol can lead to hypoglycemia, a dangerously low blood sugar level, because alcohol stimulates the release of insulin as well. That’s why experts recommend never drinking on an empty stomach. Instead, drink with a meal or at least some carbs.
    And, of course, because alcohol is made by fermenting sugar and starch, it’s full of empty calories, which contributes to obesity and type 2 diabetes.

    Mood and memory

    Because alcohol is a depressant, drinking can drown your mood. It may not seem that way while you “party” your inhibitions away, but that’s just the drink depressing the part of the brain we use to control our actions. The more you drink, say experts, the more your negative emotions, such as anxiety, anger and depression, can take over.
    That’s why binge drinking or drinking a lot in one sitting is associated with higher levels of depression, self-harm, suicide and violent offending.
    Binge drinking is also associated with severe “blackouts”: the inability to remember what happened while drunk. Blackouts can range from small memory blips, such as forgetting a name, to more serious incidents, such as forgetting an entire evening.
    Alcohol does this by decreasing the electrical activity of the neurons in your hippocampus, the part of the brain responsible for the formation of short-term memories. Keep up that binge drinking, and you can permanently damage the hippocampus and develop sustained memory or cognitive problems.
    Adolescents are most susceptible to alcohol’s memory disruption but less sensitive to the intoxicating effects. That means they can easily drink more to feel as “drunk” as an adult would, causing even more damage to their brains.

    How you look

    Last but certainly not least, alcohol can have a significant effect on your good looks. First, it dehydrates you. That can leave your skin looking parched and wrinkled. It’s also linked to rosacea, a skin condition causing redness, pimples and swelling on your face.
    Do you know you can stink while you’re drinking? During the time your liver is processing a single drink, which is on average an hour but varies for everyone, some of it leaves your body via your breath, urine and sweat.

    See the latest news and share your comments with CNN Health on Facebook and Twitter.

    Another reason drinking can affect your looks has to do with sleep. Although even a little bit of alcohol can help you fall asleep quickly, as the alcohol is metabolized and leaves the body you may suffer the “rebound effect.” Instead of staying asleep, the body enters lighter sleep and wakefulness, which appears to get worse the more one drinks.
    A lack of sleep leads to dark circles, puffy eyes and stress. Keep it up, studies say, and you’re likely to see more signs of aging and a much lower satisfaction with your appearance.
    So the next time you head to the pub for tipple or two, remember: You could be paying a price for all that fun.

    Read more: https://www.cnn.com/2018/02/01/health/alcohol-health-weight-diabetes-memory-intl/index.html

    Does talcum powder cause cancer? A legal and scientific battle rages

    (CNN)Visitors who walk into Deborah Giannecchini’s ranch house in Modesto, California, will notice a well-tended garden, four small dogs who greet every visitor with enthusiasm and a sign that hangs prominently displayed in her living room that reads “It’s never too late to live happily ever after.”

    She got it when she was 62 years old, after she married her husband, Leland, but it could also represent her current mission: to help other women avoid the pain she’s experienced and allow them to have their own happy endings.
    Giannecchini is living with what is considered terminal ovarian cancer. “That’s what they say. I’m trying to prove that it’s not,” she said. “I don’t wish this on anyone else. And if I can save one person, then I’ve done my job.”
      She and thousands of others claim that they got their ovarian cancer after using a common toiletry as a part of their daily feminine hygiene routine. They used talc-based powder, commonly referred to as talcum powder or baby powder,though some baby powder products are cornstarch-based.Cornstarch products are not believed to cause any health problems.
      Some 4,800 women and their families have now sued pharmaceutical giant Johnson & Johnson, which has sold the talc-based product Johnson’s Baby Powder for more than 100 years. Many women like Giannecchini who have sought help from the courts have said they want Johnson & Johnson to, at the very least, put a warning label on the powder.
      A handful of talcum powder companies have done just that. For example, Assured’s Shower & Bath Absorbent Body Powder says that it is “intended for external use only” and adds, “Frequent application of talcum powder in the female genital area may increase the risk of ovarian cancer.”
      Johnson & Johnson argues that sucha label would be confusing, because although the company regularly expresses sympathy for these women, it vehemently denies that its powder has anything to do with their ovarian cancer. A handful of scientists have backed the companyup in court. Andother scientists back the women’s claims.
      The topic is agrowing debate in the scientific community. Some studies have found that women face an increased risk of ovarian cancer with use of talc in the genital area, but others do not. Most suggest that more research is needed.
      At the intersection of this debate are lawyers who are putting this science under the microscope in courtrooms across the country. They’ve shown juries selective internal company memos that they say suggest Johnson & Johnson has been aware of this potential problem for decades and done nothing.
      Johnson & Johnson’s lead counsel on two of the cases argues that the lawsuits are all about the money, rather than being all about the science. “My take on the talc ovarian cancer litigation is that it really is skillful and well-funded plaintiffs lawyers who are exaggerating science and taking it out of context to scare people and to frighten the public with the goal of lining their own pockets,” Bart Williams said. “I think they are wrong scientifically. I think they are wrong legally, and I think the evidence shows that the science doesn’t support using talc and ovarian cancer.”
      Johnson & Johnson is not the only talc product manufacturer being sued over ovarian cancer claims, although most includethe company because itsproducts have dominated the market the longest.Some lawsuits mention talc makers including Valeant Pharmaceuticals, which now owns the Shower to Shower brand (owned by Johnson & Johnsonuntil 2012).
      Valeant would not grant an interview, but it sent a statement. “The safety of our products and the customers who use them are our company’s highest priority. Shower to Shower is a safe and effective product, and the scientific and medical consensus is that these products do not cause ovarian cancer,” said the statement from Lainie Keller, vice president of corporate communications for Valeant Pharmaceuticals International Inc. “It’s important to note that the lawsuits nearly all allege use of Shower to Shower prior to 2012 when our company acquired the product. Given our limited role and the strong legal, factual and scientific defenses, we do not believe claims will be established successfully against our company.”
      Other lawsuits mention Gold Bond’s talcum powder, manufactured by Chattem Inc., a Sanofi company, which did not respond to requests for comment.
      Some lawsuits include Imerys Talc America, which mines the talcin some of the powders. “We remain confident in the consensus of government agencies and professional scientific organizations that have reviewed the safety of talc, that talc is safe,” Gwen Myers, a spokeswoman for Imerys Talc America, said in a statement. “Imerys Talc America sympathizes with women suffering from ovarian cancer and hopes that the scientific community’s efforts will be directed toward finding the true causes of this terrible disease.”
      One related batch of lawsuits against Johnson & Johnson argues that its Baby Powder is contaminated with asbestos and that asbestos is causing women to develop the cancer mesothelioma. The two minerals are often mined near each other, although since the 1970s, talc used in all consumer products has been required to be asbestos-free. Johnson and Johnson says their talc does not contain asbestos. A jury ruled in Johnson & Johnson’s favor in one of those asbestos lawsuits in California in November.
      The lawyers who argue that talc itself is the problem have experienced rapid success in convincing juries in South Dakota, Missouri and California that there is a cancer connection, winning hundreds of millions for their clients. In October, judges reversed two of those verdicts.
      In one case against Johnson & Johnson involving Jacqueline Fox, who died four months after a jury awarded her $72 million, a Missouri appellate court judge ruled that the Alabama woman did not use the product in Missouri and that therefore, the case should not have been heard there. The court reversed the jury verdict due to jurisdictional issues.In the other, a California case involving Johnson & Johnson and Eva Echeverria, who also died after her favorable jury verdict,the judge reversed the jury decision, saying that there was “insufficiency of the evidence as to the causation as to both defendants.”
      Each of the fivecases that has won a favorable verdict for the plaintiff is in various stages of appeal or soon will be. Johnson & Johnson won one of the talc cases in March, when a Missouri jury found that its baby powder did not cause a Tennessee woman’s ovarian cancer. Though legal teams are investigating thousands of other potential cases, what is less clear is where the science will lead and what the future will be for an iconic product that’s on bathroom shelves around the world.

      A cosmetic love

      Giannecchini has had a lifelong relationship with talcum powder. Long after she went to court to sueJohnson & Johnson and its talc supplier Imerys Talc America in 2016, she said, she found a few small bottles in an old suitcase she hadn’t used for a while.
      She’d been using Johnson & Johnson’s Baby Powder nearly every day since high school. Sometimes, she’d alsouse the Shower to Shower product, which Johnson & Johnson used to own. She liked the powders because “both felt nice,” she said. “It was smooth and made your skin smell nice and fresh. It was just part of what I did every day.”
      Her friends used it, and she knew the company’s advertising jingle by heart. “A sprinkle a day keeps the odor away,” she shyly sang ditty when she took the stand in 2016. “Have you had your sprinkletoday?”
      Health-conscious and a self-described label-reader, Giannecchini never saw anything on the powder bottle to give her pause. “If you’ve seen the ads, you know it is supposed to be a pure and innocent and harmless product that we use on babies,” she said. Like millions of others, she sprinkled away.

      Talcum powder: A short history

      Talc makes a great powder because it is among the softest minerals,reduces frictionand has a great ability to absorb oils, moisture and odor. It’s mainly mined in China, India, Brazil, Mexico and the United States, according to the US Geological Survey.Most talc isn’t actually used for cosmetics; it’s found more often in household products: the ceramics in your bathroom fixtures, the roof over your head, the paint on your wall. It’s in plastic, paper and even in the gum you chew.
      Johnson & Johnson started selling talc in 1894 after customers complained that the company’s original medicated bandages irritated their skin. To soothe it, the company’s scientific director mailed them Italian talc. It worked so well, customers also used it on their babies’ diaper rash and wrote Johnson & Johnson about it. Taking the cue, Johnson’s Toilet and Baby Powderwas born.
      Johnson & Johnson has grown into a giant $338.6 billion company offering hundreds of consumer products, medical devices and medicine, but its Baby Powder may have shaped its image the most, branding experts said, even though it doesn’t rank highest in the company’s sales.
      “Because of it, Johnson & Johnson enjoys a strong brand image as being a company that cares,” said Aimee Drolet Rossi, the UCLA Anderson School of Management marketing chairwoman. “In fact, a lot of consumers don’t understand that Johnson & Johnson is a company that makes more than Baby Powder.”
      Sales of talc-based products like general-purpose talc, baby talcum powder, perfumed talc and “liquid talcs” — perfumed liquids that can be sprayed over the body to leave a powdery feel — brought Johnson & Johnson nearly $325.2 million in 2016 alone, according to market research firm Euromonitor.
      Adults also use the powder as a dry shampoo, a foot powder and a general after-shower ritual. “I used it everywhere, like a lot of my friends did, from head to toe,” Giannecchini said.
      Some women like Giannecchini also used it for feminine hygiene. Women who sued the company have testified that they’d sprinkle it in their underwear, on their thighs to prevent chafing, on sanitary napkins and on tampons. It’s use in this area that’s concerned some scientists.

      ‘My family saved my life’

      Giannecchini didn’t know that there was some scientific concern about her favorite powder. In fact, she used it even after her ovarian cancer diagnosis, adiagnosis that came as a big surprise.
      She had gone to the ER after her family pressured her because she wascoughing constantly.
      “I didn’t come home right away from the emergency room like I thought I would,” Giannecchini said. Instead of bronchitis, like she suspected, doctors found the cancer, and it was so advanced, they had to remove her spleen and part of her stomach. The cancer spread toher colon, bowel and bladder, too. The treatment was grueling, the prognosis not good.
      Ovarian cancer, though comparatively rare, is one of the mostlethal. Withno general screening, it’s often caught late, like it was in her case.
      “It was not pleasant,” Giannecchini said. “But my family likely saved my life.”
      Giannecchini’s daughter Casey got her mom to quit her Baby Powder habit only after seeing a lawyer’s ad on TV. They’re frequently seen on late-night TV, saying things like “If you or a loved one have developed ovarian cancer after using talcum powder: call.”
      Casey gave her mother the number, and Giannecchini sent in her information. She ended up speaking with Ted Meadows at the Beasley Allen law firm in Montgomery, Alabama. Meadows would soon lead her on a legal journey halfway across the country.

      The talc team

      At the time Giannecchini called, Meadows had been working with another attorney, R. Allen Smith, on a blitz of dozensof talc cases.
      Smith and Meadows are a classic odd couple. Meadows is quiet, serious, a runner; when not consumed with work for his large firm, he roots for his alma mater, football powerhouse University of Alabama. Smith is easy to smile and quick with a story, and he looks as if he could have played for his alma mater, the Alabama rivalUniversity of Mississippi. Ole Miss memorabilia covers the walls of Smith’s small solo practitioner office in suburban Jackson, Mississippi. Where the two are in sync is on these talc cases.
      Smith learned about how women use talc in their genital area, meaning in underwear and sanitary products, whilesitting at his parents’ dinner table. His father, a retired plastic surgeon, asked whether he’d ever heard about any connection between talc and cancer. When he got home that night, Smith started googling.
      “I couldn’t believe what I saw,” he said after looking at the scientific studies and the scientific debate that followed. “And I wondered, ‘Am I the only lawyer to see this?’ “

      The scientific debate

      Smith learned that concerns about a link between talc and ovarian cancer started surfacing around 1971, when a small group of scientists wrote about finding talc particles deeply embedded in ovarian and cervical tumor tissue. The study concluded that it is “impossible to incriminate talc as a primary cause of carcinomatous changes,” based solely on what was described in the study; however, “the possibility that talc may be related to other predisposing factors should not be disregarded.” The authors hoped more people would research the issue.
      Dr. Daniel Cramer at Harvard took up the challenge in a study published in 1982. He compared records from more than 400 women and found that women who had ovarian cancer were more likely to have used talc in their genital areas.
      Cramer conductedsubsequent studies and became the first American scientist to raise alarm bells about using talc in the genital area, but his work was not alone. The conceptcomes up more than 100 times in PubMed, a search engine for medical studies, since 1971, and the results are mixed. Some study reviews show a moderate risk. A few show that it “does not appear to influence cancer risk.“Most are population-based studies and cannot prove a direct cause-and-effect relationship.
      In general, cancer causes are tricky to prove, since it takes time for cancer to develop and it can be influenced by a wide variety of factors.
      “When it comes to talc and cancer, the message is not straightforward. It’s not necessarily black and white, and it’s a bit more complicated to explain to the layperson,” said Dr. Paolo Boffetta. The professor of medicine, hematology and medical oncology at Mt. Sinai was in the room in 2006 when the International Agency for Research in Cancer, which falls under the World Health Organization, decided to classify the use of talc in the genital area as “possibly carcinogenic to humans.”
      Based on his own research, Boffetta found, “there seems to be a small increase or risk for women who are heavy users of genital talc,” he said. “However, we don’t necessarily know what causes it.”
      Boffetta, who also thinks more research is necessary, believes that talc use in the genital area, while not a strong cancer risk factor like smoking, “may be a real factor in some cases.”
      However, some studies have found no connection at all. A 2014 study of more than 61,000 postmenopausal women in the Women’s Health Initiative Observational Study suggested that talc use in the genital area “does not appear to influence ovarian cancer risk.” A study in 2016 found that douching rather than talc was associated with an increased risk of ovarian cancer after looking at more than 50,000 women enrolled in the Sister Study, a national research study for risk factors for breast cancer.
      The research that fits into the modest association category includes a 2016 study focused on talc use in the genital area in black women. Researchers looked at nearly 600 cases of ovarian cancer and found a “modestly stronger association” with people who used talc. That risk increased more in those who used it below the belt. Author Dr. Joellen Schildkraut, an epidemiologist at the University of Virginia in Charlottesville, also believes that more research is needed.
      There are some theories that talc may cause an inflammation that can become cancer, but that idea is still being tested. “I don’t think we have definitive evidence that this causes ovarian cancer, but I do think we have a hypothesis that there is a connection. Looking at my data, it should give people pause for concern,” Schildkraut said. “It is not a necessary item to use, so why take a chance with it?”
      The most recent studies seem to suggest a small connection. A January meta-analysis, or review of 24 case-control and three cohort studies, found “a consistent association” between talc use and ovarian cancer. “Some variation in the magnitude of the effect was found when considering study design and ovarian cancer subtype,” the study said.A July meta-analysisof27 studies found a “weak but statistically significant association between genital use of talc and ovarian cancer, which appears to be limited to serious carcinoma with suggestion of dose-response.”
      An August review and meta-analysis in Epidemiology found that “in general, there is a consistent association” between talc use and ovarian cancer.
      Dr. Graham Colditz, who has been used as an expert for the plaintiffs in some of the lawsuits, thinks there is a connection.
      “The evidence has really accumulated over decades and multiple studies,” said Colditz, the Niess-Gain Professor of Surgery at Washington University School of Medicine in St. Louis and deputy directorof prevention and control at the Siteman Cancer Center. He believes the testing methods have improved since the 2014 study found no connection and scientists have gotten a better handle on understanding the duration and frequency of use of the product and how a lifetime burden of exposure may create an association.
      “That evidence has really come together and built over nearly 30 years now,” Colditz said. “This kind of science takes time.”
      US and international government agencies and medical associations that track what causes cancer seem to fall in the need-more-research camp. According to Johnson & Johnson’s website, it sells its talc products around the world, but there are some restrictions on the way talc can be used in cosmetics and baby products in the European Union and in Canada.
      The US National Toxicology Program, part of the US Department of Health and Human Services, keeps a congressionally mandated list of “agents, substances, mixtures, and exposure circumstances that are known or reasonably anticipated to cause cancer in humans.” Talc is not among the 248 listed; however, in 2010, when it was up for consideration to be included in the list, the agency explained that has not fully reviewed talc as a possible carcinogen.
      “The NTP deferred consideration of listing talc (asbestiform and non-asbestiform talc) in the 10th RoC because its 2000 review of talc found that there has been considerable confusion over the mineral nature and consequences of exposure to talc, both containing asbestiform fibers and not containing asbestiform fibers. It has become evident that the literature on both forms of talc, with a few exceptions, provides an inadequate characterization of the actual materials under study to enable one to reach definitive conclusions concerning the specific substances responsible for the range of adverse health outcomes reported.”
      The National Cancer Institute website points to the 2014 study that doesn’t find a link and suggests that “the weight of evidence does not support an association between talc exposure and an increased risk of ovarian cancer,” although it also includes talc in a list of factors for which “it is not clear whether the following affect the risk of ovarian, fallopian tube and primary peritoneal cancer.”
      The American Cancer Society also says talc’s relation to cancer “is less clear” and “findings have been mixed.” It adds that “although there is some suggestion of a possible increase in ovarian cancerrisk,” its bottom-line advice is, “Until more information is available, people concerned about using talcum powder may want to avoid or limit their use of consumer products that contain it.”

      Laying out the case

      Smith spent about five more years immersed in talc research. He joined ovarian cancer associations. He’d visit experts on free nights and weekends. He read ovarian cancer blogs.
      Late one night, reading a blog, Smith saw a question from Deane Berg of South Dakota, who shared that she was a longtime talc user who had ovarian cancer. She’d read some of the talc cancer studies and wondered whether anyone knew anything about it. “So, I immediately (replied to her) and said ‘I’ve been investigating this,’ ” Smith said.
      Smith asked whether he could help, and Berg sent her medical records. Smith also got tissue samples of her ovarian cancer tumors and sent those along with the records to some of the experts he had met.
      One of those experts was Cramer, who had done the 1982 study. Cramer later testified that he found no family history or genetic predisposition to ovarian cancer in Berg’s records. Smith also sent the tissue sample to Harvard pathologist Dr. John Godleski, who found talc in Berg’sovarian cancer tissue, Smith said.
      “I asked them, could they come to court and state scientifically to a reasonable degree of medical certainty that talc was a contributing factor to Mrs. Berg’s ovarian cancer,” Smith said,”and they said ‘absolutely, yes.’ ”
      Johnson & Johnson tried to get Godleski excluded as an expert in court, but the court determined that he was qualified, “and the opinion is relevant and stems from reliable methodologies.” Johnson & Johnson went on to challenge his findings in court.

      The cases begin

      Smith decided, even as a solo practitioner, he could take on the pharmaceutical giant. He personally sifted through hundreds of thousands of records from Johnson & Johnson. “I printed out all the documents on my computer, had them stacked all around this office, filing every space. And every day for 10 months, for 10 hours a day, I looked through the documents one by one,” Smith said. “I could not believe what I would discover.”
      Godleski’s report on Berg’s cancer, which was read at trial, said that “based on the findings in this case, it can be stated to a reasonable degree of medical certainty that the talc found in this case is evidence for a causal link between the presence of talc and the development of the patient’s ovarian cancer.”
      Smith won the first talc powder case in the country in 2013. The jury found that Johnson & Johnson was negligent, but it didn’t award Berg any damages. “So, it was kind of a bittersweet result,” Smith said. “But from there, I knew this was a much larger issue.”
      When news of the trial spread, Smith’s eventual law partner on the case, Meadows, wrote a short article for his firm’s newsletter about Smith’s win. Legal experts say it’s incredibly difficult to prove exposure to a particular product may be linked to cancer. A win in South Dakota, even without damages, meant Smith might be on to something. Meadows thought after his article came out that he’d hear from women who might be interested in bringing their own cases.
      Instead, Smith called.

      A legal whirlwind

      Other women with ovarian cancer had contacted Smith. More potential cases meant more work than Smith could handle. He and Meadows decided to work together and started flushing out what became a winning strategy, at least with juries.
      In 18 months, half a dozen juries had ruled in their clients’favor, awarding tens orhundreds of millionsto five ofthe six plaintiffs in individual cases. One of those women was Giannecchini. She flew to St. Louis in 2016 and listened to every word of her trial.
      “I learned a lot from them, although it was strange to hear about your life this way,” she said. “I’m kind of a private person, so sharing every little bit of your life wasn’t easy for me, but I just felt like it was something that I had to do.”
      In court, a black cardigan wrapped around her shoulders, Giannecchini talked about how the grueling cancer treatment had left her with little energy, but she was determined to live. An attorney from her team showed a series of pictures Giannecchini would take with her grandchildren every Easter. They paused to look at one where she is surrounded by five grandkids, all dressed in robin’s egg blue. In the picture, Giannecchini wears a lavender headscarf, covering what she called her “old bald head” from chemo. “I decided to just embrace that and say ‘this is what cancer does,’ ” Giannecchini said.
      In Giannecchini’s case, and in the others, legal teams have to show general causation and specific causation. That means people with medical expertise or scientists who have peer-reviewed research on the topic have to explain how using talc in the genital area is connected to cancer and that it caused the harm in these particular cases. The strategy varies from case to case, but Giannecchini’s legal team has also regularly argued that Johnson & Johnson knew about these health concerns and ignored them. Johnson & Johnson’s legal teamhas presented experts showingthere is no link between its products and cancer.

      Johnson & Johnson’s defense

      Dr. Patricia Judson-Lancaster, an obstetrician-gynecologist now based in Utah, has testified on behalf of Johnson & Johnson. In Giannecchini’s case, she said that “talc has no relevance to ovarian cancer.”
      “Cancer is caused by genetic mutations,” she told the jury. “We don’t know what causes those gene mutations in ovarian cancer, but we specifically know from studies that talc does not cause mutations in genes,” she said, reiterating, “talc does not cause gene mutations.
      “Talc is not the cause,” she emphasized. “I almost wish it was the cause; it would be such the simple thing to do.”
      Joshua Muscat, a professor of public health sciences in the college of medicine at Penn State who also has testified for Johnson & Johnson as an expert, agreesthatthere is no link. He authored a review article looking at past studies about talc use in thegenital area.
      “We conclude that the weak statistical associations observed in a number of epidemiological studies do not support a causal association,” he said. Unlike most other scientists, he said he doesn’t think more research on the topic is necessary. He thinks the issue is settled.
      Williams, one of the lawyers for Johnson & Johnson, said that “hard science” studies in animals and human cells, compared with epidemiological studies that show a possible association, do not show that talc causes cancer, and that’s the key.
      “The most compelling argument, I think, is trying to get juries to focus on the notion that correlations or association is not the same as causation,” Williams said. “So an example we use is bald men and hats. Just because bald men wear hats more often than men who have a full head of hair doesn’t mean that wearing the hats makes their hair fall out. There is an association, a correlation, but there isn’t a cause there. Wearing a hat has nothing to do with male pattern baldness, scientists will tell you.”

      An end and a beginning

      The jury in Giannecchini’s case decided that there was an association between talc and cancer. In October 2016, it awarded her $70 million. The decision is on appeal.
      Hers came asone ofa string ofseparatejury verdicts against Johnson & Johnson. In February 2016, a jury awarded Jacqueline Fox $72 million. In May 2016, a jury awarded Gloria Ristesund $55 million. A year later, in May, a jury awarded Louis Slemp $110 million. And in August, Eva Echeverria got an award of $417 million. Johnson & Johnson won one case in March of last year, and in June, there was a mistrial. In total, juries have handed out $724.5 million in separate decisions. But that is not the end of the story.
      Judges have not completely agreed with these jury decisions, and two have been reversed. The Fox case was reversed on jurisdictional issues: The plaintiff lived in Alabama, and Johnson & Johnson is based in New Jersey. The case was heard in St. Louis, which a judge determined wasn’t allowed based on an unrelated court ruling in June.
      The other, the Echeverria case, was thrown out based on science. The judge cited”insufficiency of the evidence as to the causation as to both defendants,” Johnson & Johnson and its consumer products subsidiary.
      She also ruled that there was error in law occurring at trial and misconduct of the jury, which led to excessive damages.
      “That ruling may have taken the wind out of the sails of these cases, but it shouldn’t be a permanent setback,” said Jean Eggen, the distinguished professor emerita of law at Widener University Law School in Delaware. “These are early days still.”
      Litigation like this, unlike criminal law, “can take forever,” and “cancer is always very complicated to prove.” With tobacco and asbestos, it took decades before the science showed, and the courts believed that there may be a connection,” Eggen explained. “It does make you wonder what the next part of the story will be.”
      As far as Johnson & Johnson is concerned, it has said it will continue to fight these cases.

      See the latest news and share your comments with CNN Health on Facebook and Twitter.

      Smith and Meadows — and dozens of other attorneys involved in these cases — are determined to get their day in court. “What the future holds for this litigation, I don’t know,” Smith said. “I hope and pray at a minimum Johnson & Johnson will at least put a warning label on their product.”
      Williams, one of the Johnson & Johnson lawyers, thinks that putting a label on the product would be “irresponsible.”
      “I think having a cancer warning on a product that hasn’t been shown to cause cancer, it just isn’t the right thing to do,” he said. “If 40 years of animal studies and human cell studies have failed to show some causal connection in using talc anywhere on your body and ovarian cancer, and given that, putting a cancer warning on the product wouldn’t be proper.”
      Giannecchini, who watches for news of the other trials and waits for a final ruling in her own case, continues her own personal battle with cancer. Her doctors monitor her condition closely.
      “I’m fighting it,” Giannecchini said. She hopes to continue to be around to tell her story. “So far, so good. Here I am.”

      Read more: https://www.cnn.com/2018/04/11/health/talc-ovarian-cancer-cases/index.html

      A Neuroscientist Lost Her Mind From Cancer. Shes Not Alone.

      Barbara Lipska was already a two-time cancer survivor when her hand disappeared in front of her face in 2015.

      The neuroscientist and director of the Human Brain Collection Core at the National Institute of Mental Health specializes in studying schizophrenia. When she moved her right hand and it disappeared, she immediately predicted her eventual diagnosis.

      I thought right away: brain tumor, she told The Daily Beast. But I quickly expelled it. I didnt have time for brain tumors.

      Lipska, whose book The Neuroscientist Who Lost Her Mind: My Tale of Madness and Recovery was published on April 3, had already faced her own mental health challenges in the wake of battling breast cancer in 2009, then melanoma in 2011. She sought psychotherapy at the recommendation of her daughter.

      Shes not alone in needing help as a cancer patient. According to the American Cancer Society, feelings of depression, anxiety, and fear are very common in people with cancer, and up to one in 4 people with cancer have clinical depression.

      I didnt have time for brain tumors.
      Barbara Lipska, neuroscientist and author

      The mental health issues Lipska started experiencing in 2015 were extreme. There was the vision issue, her disappearing hand, and the suddenly unrecognizable faces of colleagues. There was also her memoryforgetting where she lived while out on a run and an impaired awareness of having to urinate, leading her to pee her pants. And there was also her changing personality, breakdowns and overall failure to see that she was experiencing these things. Lipska, whose entire career revolved around these kinds of behaviors caused by mental health disorders, suddenly started experiencing them herself.

      Lipskas brain tumors were metastases, secondary malignant growths in the brain that were a result of her melanoma. Her largest tumor was the size of an almond. According to the American Brain Tumor Association, melanoma is a common cancer to metastasize to the brain, along with lung, breast, and colon.

      One of Lipskas doctors, Ayal Aizer, M.D., a radiation oncologist at the Dana-Farber Cancer Institute, told The Daily Beast that there are a number of elements to consider when patients are diagnosed with metastases, namely the location of their tumors, which eventually defines how they manifest. Lipskas tumors inhabited her brains frontal cortex, which, she writes in her book, determines who humans are.

      Even if theyre small, theres a psychological aspect of having cancer in the brain which is very difficult to digest and ultimately cope with, and in addition to that, some patients who have brain metastases actually have symptoms that can impair what we value most in life like vision, coordination or speech or walking and the ability to think clearly and digest information, he said.

      It really can significantly impact the life.

      Aizer said that a patients mental healthcare is dictated by what they want or express in their unique needs. Sometimes, patients like to stick to strictly medical facts when dealing with oncologists; other times, they want to have an all-hands-on-deck approach, with psychologists, psychiatrists, even family therapists. The goal is to help patients process their mental and neurological issues, digest it, cope with it.

      Sometimes we can bring in speech and language and occupational therapists, and I think just having the opportunity to sit with a mental health professional in the office for an hour where were not talking about chemo or immunotherapy or radiation or surgery and its talking about what life is like, what challenges theyre facing and having someone to sort of listen, serve as a sounding board and come up with strategies to cope is really valuable, Aizer said.

      Lipska underwent many different treatments for the metastases, like immunotherapy, radiation, steroids and targeted therapy. And slowly, her clarity came back bit by bit, but she was entirely unaware of how shed behaved, so much so that her family had to fill her in on her behaviors.

      Today, Lipska is now in remission. Its been 16 months after the initial findings of her tumors, but shes aware there could be more cancer cells still in her body. Theres also the chance shell develop necrosis, an effect of radiation that destroys healthy brain tissue.

      But mostly, Lipska is positive, thankful. Shes happy to have her memory and brain back and to have learned so much from her experience that she can use toward her own work.

      Though shes regained her neurological function, she largely associates what she went through with what mentally ill people go through every day.

      In the course of losing and regaining my sanity, Ive come to identify with other people who have known mental illnesses firsthand, Lipska said in her book, explaining that the symptoms she exhibited fall in line with diagnoses for dementia, schizophrenia, and bipolar disorder. Despite conducting research on mental illness for over thirty years, I believe it is my own suffering that truly taught me how the brain worksand how profoundly frightening it is when our minds fail.

      Lipska said her compassion for those with mental illness is one of the many things this experience left her with.

      The brain is an incredibly complex mechanism and we have no idea what happens in people with mental illness, so theres more empathy, it gives rise to more tolerance and more passion toward research in this field and more passion to find a cure, which I spend my life working on.

      Read more: https://www.thedailybeast.com/a-neuroscientist-lost-her-mind-from-cancer-shes-not-alone

      Trump judicial nominee Wendy Vitter won’t say if segregated schools are bad.

      Asked whether she agreed with the Supreme Court’s 1954 Brown v. Board of Education decision, federal judicial nominee Wendy Vitter hesitated.

      During her confirmation hearing on Wednesday, April 11, Vitter, a nominee for a post in the Eastern District of Louisiana, was asked by Sen. Richard Blumenthal (D-Connecticut) whether or not she agreed with the landmark civil rights case that effectively ended legal segregation in schools.

      “I don’t mean to be coy, but I think I get into a difficult area when I start commenting on Supreme Court decisions — which are correctly decided and which I may disagree with,” Vitter responded. “Again, my personal, political, or religious views I would set aside.”

      Pressed on the matter, Vitter refused to clarify whether or not she believed this was a decision the court got right or whether she agreed with it, but she did say she’d uphold precedents set by higher courts if confirmed. The answer quickly drew the shock and ire of the Leadership Conference, a civil rights organization founded in 1950.

      Vitter’s history as an anti-abortion activist played a role in her hearing as well, when she was asked about Roe v. Wade.

      At an anti-abortion rally in 2013, Vitter reportedly said, “Planned Parenthood says they promote women’s health. It is the saddest of ironies that they kill over 150,000 females a year. The first step in promoting women’s health is to let them live.”

      When asked by Blumenthal whether or not she still believes her past statement, Vitter refused to answer, simply saying that she is “pro-life” but would set aside personal and religious views if confirmed. At another point, Vitter was asked about past efforts to get brochures into doctors offices that falsely claimed abortions cause breast cancer and made a dubious connection between women taking birth control and being murdered.

      Vitter and family attend her husband David’s swearing in ceremony to the U.S. Senate. Photo by Alex Wong/Getty Images.

      Vitter is just one of many controversial Trump judicial nominees who would receive a lifetime appointment if confirmed.

      Read more: http://www.upworthy.com/trump-judicial-nominee-wendy-vitter-won-t-say-if-segregated-schools-are-bad